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Partial-onset seizures include:
Simple partial seizures, where a person remains fully aware (does not lose consciousness). He/she may:
- Experience muscle jerking or stiffening
- Smell, taste, see, hear, or feel things that are not there
- Experience a sudden sense of fear, depression or happiness
- Have changes in heart rate or breathing, sweating, or goose bumps
Complex partial seizures, where a person loses awareness (either partially or fully). He/she may:
- Stare blankly or may seem to be daydreaming
- Pick at the air or their clothing
- Repeat words or phrases
If you are experiencing partial-onset seizures on your current antiepileptic medicine, your doctor may recommend switching your medicine or adding another antiepileptic medicine to your treatment to help with seizure control. This additional medicine is called an "add-on therapy" or "adjunctive therapy".
BRIVIACT® (brivaracetam) CV is a prescription medicine that can be used to treat partial-onset seizures in people 1 month of age and older. In clinical studies, patients who added BRIVIACT to their current antiepileptic treatment had fewer partial-onset seizures compared to patients who were taking a placebo and their current medicine(s). This means that BRIVIACT may provide you with additional seizure control without the need to switch from your current treatment.
Controlling your partial-onset seizures may mean taking more than one antiepileptic medicine. BRIVIACT is a prescription medicine that can be used to treat partial-onset seizures in people 1 month of age and older.
When BRIVIACT is added to existing antiepileptic medicines, it may:
- Reduce the number of partial-onset seizures in people 1 month of age and older who are currently taking one or more antiepileptic medicines
- Provide additional seizure control:
- without having to give up the benefits of your current antiepileptic medicine(s)
- even if you have tried or are taking multiple antiepileptic medicines
In clinical trials:
- BRIVIACT was added to 1 to 2 common antiepileptic medicines, including DEPAKENE® (valproic acid), Dilantin® (phenytoin), KEPPRA® (levetiracetam), LAMICTAL® (lamotrigine), Lyrica® (pregabalin), phenobarbital, Tegretol® (carbamazepine), Topamax® (topiramate), Trileptal® (oxcarbazepine), VIMPAT® (lacosamide), and Zonegran® (zonisamide)
- Some patients were also being treated with vagal nerve stimulation (VNS)
- The most common side effects of BRIVIACT include sleepiness, dizziness, feeling tired, and nausea and vomiting. Most of these side effects were reported to be mild to moderate
Starting Day One with BRIVIACT:
- Your doctor will tell you how much BRIVIACT to take and when to take it. You start with the full recommended dose from day one. BRIVIACT does not require titration – which means that you do not need to increase your dose over several weeks. See Taking BRIVIACT for complete information on taking BRIVIACT
BRIVIACT may not be for everyone. You and your doctor should discuss the possible benefit and risks of treatment with BRIVIACT.
The exact way that BRIVIACT works is not yet fully understood, but it is thought that BRIVIACT reduces the frequency of partial-onset seizures by binding to synaptic vesicle protein 2A (SV2A) in the brain.
- Take BRIVIACT exactly as your healthcare provider tells you. He or she will tell you how much BRIVIACT to take and when to take it
- Take your prescribed dose on day one. BRIVIACT does not require titration — this means that you do not need to increase your dose over several weeks
- For adults, the recommended starting dose is 50 mg twice daily (100 mg per day)
- Your healthcare provider may change your dose if needed. For adults, he or she may lower the dose to 25 mg twice daily (50 mg per day) or increase your dose to 100 mg twice daily (200 mg per day)
- Do not stop BRIVIACT or change your dose without talking to your healthcare provider
- Take BRIVIACT with or without food
- Swallow BRIVIACT tablets whole with a liquid. Do not chew or crush BRIVIACT tablets before swallowing
- Do not take BRIVIACT if you are allergic to brivaracetam or any of the ingredients in BRIVIACT
- If your healthcare provider has prescribed BRIVIACT oral solution, be sure to ask your pharmacist for a medicine dropper or medicine cup to help you measure the correct amount of BRIVIACT oral solution. Do not use a household teaspoon. Ask your pharmacist for instructions on how to use the measuring device correctly
- If you take too much BRIVIACT, call your Poison Control Center at 1-800-222-1222 or go to the nearest emergency room right away
Your doctor will tell you how much BRIVIACT to take and when to take it. You start with the full recommended dose from day one. BRIVIACT does not require titration – which means that you do not need to increase your dose over several weeks.
Taking your epilepsy medicine exactly as your doctor recommends is one of the most important things you can do to help manage your seizures. Do not stop taking your medicine if your seizures become less frequent or stop altogether. BRIVIACT is a daily treatment, so you must continue taking it until your doctor tells you to stop. If your doctor decides to stop your BRIVIACT treatment, he or she will give you instructions on how to slowly stop taking BRIVIACT.
Do not stop taking BRIVIACT without first talking to a healthcare provider. Stopping BRIVIACT suddenly can cause serious problems, including seizures that will not stop (status epilepticus).
If you take too much BRIVIACT, call your Poison Control Center at 1-800-222-1222 or go to the nearest emergency room right away.
Do not drive or operate heavy machinery until you know how BRIVIACT affects you. BRIVIACT may cause drowsiness, tiredness, dizziness, and problems with your balance and coordination.
Before taking BRIVIACT, tell your healthcare provider about all of your medical conditions, including if you are pregnant or plan to become pregnant. It is not known if BRIVIACT will harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking BRIVIACT. You and your healthcare provider will have to decide if you should take BRIVIACT while you are pregnant.
Before taking BRIVIACT, tell your healthcare provider about all of your medical conditions, including if you are breastfeeding or plan to breastfeed. It is not known if BRIVIACT passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take BRIVIACT.
The most common side effects of BRIVIACT in adults include1:
- feeling tired
- nausea and vomiting
Side effects of BRIVIACT in children 1 month to less than 16 years of age are similar to those seen in adults.
These are not all the possible side effects of BRIVIACT. For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider about any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects.
Please see additional patient information in the Medication Guide. This information does not take the place of talking with your healthcare provider about your condition or your treatment.
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